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mRNA Vaccines
The formulation and the technological advancements in RNA biology, chemistry, stability, and encapsulated delivery systems that have enabled the development of fully synthetic mRNA vaccines are discussed in this volume.The applications of the mRNA technology is covered, focusing on infectious diseases but also touching on other indications, such as immunotherapies and molecular therapies.Potent and long-lasting immune responses observed in animal models, encouraging data from early human clinical studies, together with the success of two mRNA-based COVID-19 vaccines support the use of mRNA-based vaccination as an attractive alternative to conventional vaccine approaches.Consequently, the development progress of the technology, particularly on production, capabilities, and clinical development is reviewed.Topics on safety, regulatory issues, and possible challenges to the mRNA vaccination approach round off this book.Thanks to their high potency, the prospect for generic,low-cost manufacturing processes, and entirely synthetic nature, the future for mRNA vaccines is highly promising.Importantly, mRNA vaccines have the potential to minimize the time between pathogen identification and vaccine release with a huge impact on public health.As the mRNA-based vaccination technology has been progressing rapidly, the book is intended to be an end-to-end review series, covering everything from basic RNA biology and preclinical studies to the manufacturing strategy, clinical development and regulatory approval.It provides established RNA researchers and developers with updates on the latest advancements in the field and allows for a quick but comprehensive overview of this transformative technology, its application, and future potential.
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Trends in mRNA Vaccine Research
The authoritative guide to the revolutionary concept behind the successful Covid-19 vaccines In Trends in mRNA Vaccine Research, a team of distinguished researchers delivers a practical and up-to-date discussion of the biochemical and biomedical foundations of mRNA vaccines.They also explore the manufacturing conditions required for successful vaccine development and review recent progress in a variety of medical fields, including vaccines against pathogens like SARS-CoV-2, HIV, plasmodium, Mycobacterium tuberculosis, as well as anticancer vaccines.Volume highlights include: A historical overview of mRNA vaccine developmentImmune responses to modified or unmodified mRNA vaccinesA description of the different mRNA vaccine platformsLatest data on current mRNA vaccine developments against infectious diseases and cancer Perfect for medicinal chemists, immunologists, and epidemiologists, Trends in mRNA Vaccine Research will also benefit researchers and scientists working in the pharmaceutical industry, as well as cancer researchers with an interest in vaccine development.
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Web Accessibility Cookbook: Creating Inclusive Experiences
Web Accessibility Cookbook: Creating Inclusive Experiences
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Web Accessibility Cookbook : Creating Inclusive Experiences
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Equality, Participation and Inclusion 1 : Diverse Perspectives
What are the experiences of children and young people?How can we think about the challenges they face?What systems and practices can support them?How can we develop greater equality, participation and inclusion across diverse settings?This second edition of Equality, Participation and Inclusion 1: Diverse Perspectives is the first of two Readers aimed at people with an interest in issues of equality, participation and inclusion for children and young people.This first Reader focuses in particular on the diverse perspectives held by different practitioners and stakeholders.Comprising readings taken from the latest research in journal articles, newly commissioned chapters, as well as several chapters from the first edition that retain particular relevance, this fully updated second edition has broadened its focus to consider a greater diversity of perspectives.Whilst exploring how we think about the experiences of children and young people across a range of contexts it maintains a subtle, underlying emphasis upon education and the experiences of disabled people. Drawing on the writing of academics, practitioners, children and young people, and people who have experienced exclusion, this book is a rich resource for students and practitioners who are interested in thinking about how inequality and exclusion are experienced, and how they can be challenged.Much of the material reflects on lived experiences and life stories, and will be of particular interest to those working in education, health, youth and community work, youth justice and social services, as well as to families and advocates.
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Breaking Down Barriers : Usability, Accessibility and Inclusive Design
The Cambridge Workshops on Universal Access and Assistive Technology (CWUAAT) is one of the few gatherings where people interested in inclusive design, across different fields, including designers, computer scientists, engineers, architects, ergonomists, ethnographers, policymakers and user communities, meet, discuss, and collaborate.CWUAAT has also become an international workshop, representing diverse cultures including Portugal, Germany, Trinidad and Tobago, Canada, Australia, China, Norway, USA, Belgium, UK, and many more. The workshop has five main themes based on barriers identified in the developing field of design for inclusion: I Breaking Down Barriers between Disciplines II Breaking Down Barriers between Users, Designers and Developers III Removing Barriers to Usability, Accessibility and Inclusive Design IV Breaking Down Barriers between People with Impairments and Those without V Breaking Down Barriers between Research and Policy-making In the context of developing demographic changes leading to greater numbers of older people and people living with impairments, the general field of inclusive design research strives to relate the capabilities of the population to the design of products, services, and spaces.CWUAAT has always had a successful multidisciplinary focus, but if genuine transdisciplinary fields are to evolve from this, the final barriers to integrated research must be identified and characterised.Only then will benefits be realised in an inclusive society.Barriers do not arise from impairments themselves, but instead, are erected by humans, who often have not considered a greater variation in sensory, cognitive and physical user capabilities.Barriers are not only technical or architectural, but they also exist between different communities of professionals.Our continual goal with the CWUAAT workshop series is to break down barriers in technical, physical, and architectural design, as well as barriers between different professional communities.
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Aiding Empowerment : Democracy Promotion and Gender Equality in Politics
In recent decades, women's political empowerment has become an important foreign policy and assistance objective.Every year, donor governments and multilateral organizations partner with hundreds of civil society groups around the world to train women to run for office, support women legislators, campaign for gender quotas, and bolster women's networks in political parties and parliaments. What ideas about gender, power, and political change guide these aid programs?What have practitioners and advocates learned about their strengths and weaknesses, and how might they improve their work going forward? Drawing on extensive interviews with aid officials, women's rights advocates, and women politicians in Western donor countries and across Kenya, Morocco, Myanmar, and Nepal, Aiding Empowerment investigates how democracy aid actors promote gender equality in politics.Saskia Brechenmacher and Katherine Mann argue that international assistance for women's political empowerment has evolved significantly over the last three decades, from a first generation of aid programs aimed at integrating women into nascent democratic institutions to a second generation focused on transforming the broader political ecosystem hindering women's equal political influence.However, this evolution is still unfolding, and changes in thinking have outstripped changes in aid practice.Several challenges threaten future progress, from the persistence of patriarchal norms to rising concerns about democratic erosion and backlash.In the face of these hurdles, the book presents practical recommendations for policymakers, practitioners, and advocates fighting for women's political empowerment globally.
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Belonging (Lifebuilder Bible Study) : Accessibility, Inclusion and Christian Community
God created all of us to be in relationship with him and with each other.Yet for those with disabilities, attitudes and systems of ableism create barriers to fully participating in God's kingdom work, as well as leading to deep hurt – and when any members of the body of Christ are not included, we all miss out. In Belonging, Deborah Abbs guides us through nine Bible studies on inclusion.Exploring the deep love and acceptance of our heavenly Father, she shows us what that means for offering love and acceptance to one another.In both Old and New Testament stories and teachings on Christian community we see how God responds in love to those who are often marginalized and excluded. In turn, through these examples and lessons we can see the importance of disability inclusion in church and learn to welcome people of all different abilities. Part of the LifeBuilder Bible Studies series, Belonging features questions that can be used both individually or in small groups.It is a brilliant resource for anyone wanting to understand Biblical teaching on inclusion and acceptance better, and for those wanting to make their church a more welcoming place for those with disabilities.
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